課程資訊
課程名稱
新藥探索一
NEW DRUG DISCOVERY(Ⅰ) 
開課學期
97-1 
授課對象
學程  分子醫藥學程  
授課教師
李水盛 
課號
PHARM7004 
課程識別碼
423 M0070 
班次
 
學分
全/半年
半年 
必/選修
選修 
上課時間
星期四3,4(10:20~12:10) 
上課地點
 
備註
本課程中文授課,使用英文教科書。在基1234上課.與陳燕惠、林文貞、楊雅雯、陳基旺、孔繁璐、忻凌偉、沈麗娟、沈雅敬、林君榮合開
總人數上限:40人 
 
課程簡介影片
 
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課程概述

1. Introduction/Natural products for drug discovery (1)
2. Natural products for drug discovery (2)
3. Compounds from chemical synthesis
4. Combinatory chemistry in drug discovery process
5. Molecular similarity methods and QSAR models for virtual screening
6. In vitro assay models/high throughput screening tests
7. Animal models/in vivo efficacy study
8. Mechanism study/general and safety pharmacology
9. Microarray and analysis
10. Strategies and methods in monitoring and targeting protein-protein interaction
11. Pharmacokinetics study
12. Drug transport
13. Formulation/drug delivery system (1)
14. Formulation/drug delivery system (2)
15. Toxicology in drug discovery
16. Contract Research Organization in the work of clinical, regulatory and compliance services
17. Clinical trials

 

課程目標
 
課程要求
 
預期每週課後學習時數
 
Office Hours
 
指定閱讀
 
參考書目
Drug Discovery. Edited by Shayne C. Gad (2005).
High Throughput Screening-methods and protocols. Edited by William P. Janzen (2002).
Biopharmaceuticals: Biochemistry and Biotechnology. Edited by Gary Walsh (1998).
Advances in Drug Discovery Techniques. Edited by Alan L. Harvey

 
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